The party comes across a magic amulet. This amulet will give each user two wishes, but the wishes almost seem to have a mind of their own.
Missions for any campaign in any city of any realm. As long as crime exists, you will be able to use this submission.
The PCs are accosted in a major city containing at least one famous fortuneteller / prophet of the future. They are informed that their as-yet-unborn child will (insert terrible evil), and that, although they are very sorry, the PC must be executed to keep this from happening.