Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
The spirit of a creature trapped in amber cannot escape to it’s afterlife / next incarnation / whatever.
Such trapped spirits can be contacted by those who know the right rituals and magical power derived from them – typically the power to control one individual of that species.
Can by quite powerful if the creature is a colony insect (ant, bee, wasp, etc) – simply control the queen and you command the whole colony.