Plagues and other great diseases are important parts of history and some settings. They defy man and may even defy God in their swift and terrible punishment upon the body of society.
Most large mammals, such as elephants, rhinos, and their modern ilk are ill-suited for domestication, but that doesnt exclude their use as engines of war. Rather than raise and train the Mammoth from birth, Mammoth Handlers instead capture the wild Mammoths at a young to juvenile age and train them for war. These animals are draped in armor and are unleashed as living war machines against the foes of the Mammoth Tribe.