The mind of a wizard is more open to the more esoteric elements of his surroundings - this is why he is able to perceive the weave of the Great Tapestry that is the multiverse, and pull at the strings. This increased sensitivity can manifest in several ways.
A weapon of war created by an extinct race, this rat appears normal but is a simulacrum - beneath it’s mangy fur is a body of bronze. Commanded by words in a lost language, wherever it goes a virulent and lethal plague follows. The cure is similarly obscure.